Paraneoplastic thrombocytosis: the secrets of tumor self-promotion.

Blood Spotlight Paraneoplastic thrombocytosis: the secrets of tumor self-promotion

Normally quiescent platelets in the circulation respond to localized breaches in vascular integrity by providing hemostasis with swiftness and precision. They do so by mobilizing their remarkable repertoire of capabilities to respond to injury: adhesion, activation, secretion, aggregation, recruitment, and wound healing. However, only in recent years have we begun to appreciate the functional v...

Paraneoplastic thrombocytosis in ovarian cancer.

BACKGROUND The mechanisms of paraneoplastic thrombocytosis in ovarian cancer and the role that platelets play in abetting cancer growth are unclear. METHODS We analyzed clinical data on 619 patients with epithelial ovarian cancer to test associations between platelet counts and disease outcome. Human samples and mouse models of epithelial ovarian cancer were used to explore the underlying mec...

Prognostic Significance of Anemia, Leukocytosis and Thrombocytosis in Chinese Women with Ovarian Cancer

Approximately 95% of ovarian cancers are of epithelial origin. In 2013, there were 22,240 estimated new diagnoses of ovarian cancer and 14,030 deaths from the disease (Siegel et al, 2013). The high mortality of epithelial ovarian cancer (EOC) is mainly due to latestage diagnosis for more than 70% of patients. Recently, paraneoplastic syndromes have been proved in playing a causal role in poor p...

Role of interleukin-6 in paraneoplastic thrombocytosis.

Primary Small Cell Carcinoma of the Esophagus (PSCEC) Associated with Paraneoplastic Sweating Syndrome: A Case Report and Literature Review

Introduction: Primary small cell carcinoma of theesophagus (PSCEC) associated with paraneoplastic sweating syndrome is a rare disease characterized with rapid growth rate, metastasis at the time of diagnosis, and poor prognosis. The lung is the most common site for small cell carcinoma but this malignancy includes 0.1% to 1% of all gastrointestinal and 0.8% to 2.7% of esophageal malignancies. ...